Assay Detail
Binding
CHEMBL1005557
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Inhibition of human recombinant MAOA
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.84 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL457535 | — | — | 1 | 5.56 |
| CHEMBL524447 | — | — | 1 | 5.45 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 5.35 |
| CHEMBL497675 | — | — | 1 | 5.32 |
| CHEMBL497674 | — | — | 1 | 5.31 |
| CHEMBL508324 | — | — | 1 | 5.26 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.18 |
| CHEMBL497676 | — | — | 1 | 5.17 |
| CHEMBL456150 | — | — | 1 | 5.14 |
| CHEMBL498683 | — | — | 1 | 4.51 |
| CHEMBL496279 | — | — | 1 | 4.45 |
| CHEMBL498505 | — | — | 1 | 4.42 |
| CHEMBL502371 | — | — | 1 | 4.38 |
| CHEMBL498694 | — | — | 1 | 4.37 |
| CHEMBL453703 | — | — | 1 | 4.36 |
| CHEMBL496280 | — | — | 1 | 4.36 |
| CHEMBL496281 | — | — | 1 | 4.35 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 4.17 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL457535 | — | IC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL524447 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL497675 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL497674 | — | IC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL508324 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL497676 | — | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL456150 | — | IC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL498683 | — | IC50 | = | 31030.0 | nM | 4.51 |
| CHEMBL496279 | — | IC50 | = | 35220.0 | nM | 4.45 |
| CHEMBL498505 | — | IC50 | = | 37950.0 | nM | 4.42 |
| CHEMBL502371 | — | IC50 | = | 41230.0 | nM | 4.38 |
| CHEMBL498694 | — | IC50 | = | 42310.0 | nM | 4.37 |
| CHEMBL453703 | — | IC50 | = | 43950.0 | nM | 4.36 |
| CHEMBL496280 | — | IC50 | = | 43550.0 | nM | 4.36 |
| CHEMBL496281 | — | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL972 | SELEGILINE | IC50 | = | 67250.0 | nM | 4.17 |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | = | 361380.0 | nM | - |