Assay Detail
Binding
CHEMBL1005604
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Displacement of [3H]Naltindole from human delta opioid receptor expressed in CHO cell membrane
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of hydrophobic esters and ethers of butorphanol at opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 6.98 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL592 | LEVORPHANOL | 4.0 | 1 | 8.38 |
| CHEMBL301160 | BUTORPHAN | — | 1 | 8.23 |
| CHEMBL33986 | BUTORPHANOL | 4.0 | 1 | 7.92 |
| CHEMBL499884 | — | — | 1 | 7.92 |
| CHEMBL500419 | — | — | 1 | 7.66 |
| CHEMBL521543 | — | — | 1 | 7.64 |
| CHEMBL501739 | — | — | 1 | 7.20 |
| CHEMBL500154 | — | — | 1 | 7.02 |
| CHEMBL503457 | — | — | 1 | 6.72 |
| CHEMBL500123 | — | — | 1 | 6.31 |
| CHEMBL501447 | — | — | 1 | 6.30 |
| CHEMBL524505 | — | — | 1 | 6.17 |
| CHEMBL451320 | — | — | 1 | 6.16 |
| CHEMBL497108 | — | — | 1 | 6.12 |
| CHEMBL499868 | — | — | 1 | 6.03 |
| CHEMBL526362 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL592 | LEVORPHANOL | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL301160 | BUTORPHAN | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL33986 | BUTORPHANOL | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL499884 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL500419 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL521543 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL501739 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL500154 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL503457 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL500123 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL501447 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL524505 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL451320 | — | Ki | = | 690.0 | nM | 6.16 |
| CHEMBL497108 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL499868 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL526362 | — | Ki | = | 1500.0 | nM | 5.82 |