Assay Detail
Binding
CHEMBL1005697
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human synovial recombinant group 2 secretory phospholipase A2 by liquid scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phospholipase A2, membrane associated (CHEMBL3474) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.94 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477692 | BOLINAQUINONE | — | 1 | 6.70 |
| CHEMBL517216 | DYSIDINE | — | 1 | 5.70 |
| CHEMBL463914 | MANOALIDE | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477692 | BOLINAQUINONE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL517216 | DYSIDINE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL463914 | MANOALIDE | IC50 | = | 3900.0 | nM | 5.41 |