Assay Detail
Binding
CHEMBL1005834
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Displacement of [3H]epibatidine from Aplysia californica AchBP I118M, M116L mutant expressed in HEK293S cells by scintillation proximity assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aplysia californica |
| Cell Type | HEK293S |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.34 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55716 | AZIDOEPIBATIDINE | — | 1 | 8.32 |
| CHEMBL95904 | — | — | 1 | 7.17 |
| CHEMBL95352 | THIACLOPRID OLEFIN | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55716 | AZIDOEPIBATIDINE | Kd | = | 4.8 | nM | 8.32 |
| CHEMBL95904 | — | Kd | = | 68.0 | nM | 7.17 |
| CHEMBL95352 | THIACLOPRID OLEFIN | Kd | = | 299.0 | nM | 6.52 |