Assay Detail
Functional
CHEMBL1005901
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Cytotoxicity against human HCT8 cells after 96 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phelligridins C-F: cytotoxic pyrano[4,3-c][2]benzopyran-1,6-dione and furo[3,2-c]pyran-4-one derivatives from the fungus Phellinus igniarius.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.15 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 8.82 |
| CHEMBL218423 | PHELLIGRIDIN D | — | 1 | 7.00 |
| CHEMBL520568 | PHELLIGRIDIN C | — | 1 | 6.90 |
| CHEMBL470046 | PHELLIGRIDIN B | — | 1 | 6.86 |
| CHEMBL452722 | HISPOLON | — | 1 | 6.70 |
| CHEMBL75390 | — | — | 1 | 6.64 |
| CHEMBL446850 | PHELLIGRIDIN A | — | 1 | - |
| CHEMBL236399 | PHELLIGRIDIN E | — | 1 | - |
| CHEMBL488197 | PHELLIGRIDIN F | — | 1 | - |
| CHEMBL487596 | INOSCAVIN A | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84 | TOPOTECAN | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL218423 | PHELLIGRIDIN D | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL520568 | PHELLIGRIDIN C | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL470046 | PHELLIGRIDIN B | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL452722 | HISPOLON | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL75390 | — | IC50 | = | 227.0 | nM | 6.64 |
| CHEMBL446850 | PHELLIGRIDIN A | IC50 | > | 192.0 | nM | - |
| CHEMBL236399 | PHELLIGRIDIN E | IC50 | > | 105.0 | nM | - |
| CHEMBL488197 | PHELLIGRIDIN F | IC50 | > | 104.0 | nM | - |
| CHEMBL487596 | INOSCAVIN A | IC50 | > | 108.0 | nM | - |