Assay Detail
Functional
CHEMBL1005950
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at alpha2 adrenergic receptor in human brain prefrontal cortex tissue by [35S]GTPgamma S binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Prefrontal cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor antagonists. 2. Exploring alkyl linkers for new antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 4.96 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1203971 | — | — | 1 | 5.96 |
| CHEMBL1204394 | — | — | 1 | 5.36 |
| CHEMBL844 | BRIMONIDINE | 4.0 | 1 | 4.94 |
| CHEMBL1204395 | — | — | 1 | 4.82 |
| CHEMBL1204392 | — | — | 1 | 4.45 |
| CHEMBL1204391 | — | — | 1 | 4.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1203971 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1204394 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL844 | BRIMONIDINE | EC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL1204395 | — | EC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL1204392 | — | EC50 | = | 35500.0 | nM | 4.45 |
| CHEMBL1204391 | — | EC50 | = | 62900.0 | nM | 4.20 |