Assay Detail
Binding
CHEMBL1006151
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Channel opening activity at SUR1/Kir6.2 potassium ATP channel in mouse beta-TC6 cells assessed as isometric force by FLIPR
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | C6 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 4.29 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514789 | — | — | 1 | 4.51 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 4.47 |
| CHEMBL473941 | — | — | 1 | 4.35 |
| CHEMBL491479 | — | — | 1 | 4.27 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 4.22 |
| CHEMBL11458 | — | — | 1 | 4.22 |
| CHEMBL473744 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514789 | — | EC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL49035 | CROMAKALIM | EC50 | = | 33700.0 | nM | 4.47 |
| CHEMBL473941 | — | EC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL491479 | — | EC50 | = | 53300.0 | nM | 4.27 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | EC50 | = | 60800.0 | nM | 4.22 |
| CHEMBL11458 | — | EC50 | = | 60500.0 | nM | 4.22 |
| CHEMBL473744 | — | EC50 | = | 99800.0 | nM | 4.00 |