Assay Detail
Binding
CHEMBL1006152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Channel opening activity at SUR2A/Kir6.2 potassium ATP channel in african green monkey COS7 cells assessed as isometric force by FLIPR
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Chlorocebus aethiops |
| Cell Type | COS-7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and structure-activity relationships of a novel series of benzopyran-based K(ATP) openers for urge urinary incontinence.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.45 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11458 | — | — | 1 | 6.21 |
| CHEMBL473744 | — | — | 1 | 5.78 |
| CHEMBL473941 | — | — | 1 | 5.61 |
| CHEMBL491479 | — | — | 1 | 5.50 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 5.31 |
| CHEMBL514789 | — | — | 1 | 5.09 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | 4.0 | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11458 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL473744 | — | EC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL473941 | — | EC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL491479 | — | EC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL49035 | CROMAKALIM | EC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL514789 | — | EC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL1159 | PINACIDIL ANHYDROUS | EC50 | = | 21600.0 | nM | 4.67 |