Assay Detail
Binding
CHEMBL1006200
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Inhibition of nAChR-mediated nicotine-evoked [3H]DA release in superfused rat striatal slices
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.33 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239844 | — | — | 1 | 9.70 |
| CHEMBL54331 | — | — | 1 | 8.70 |
| CHEMBL451671 | — | — | 1 | 8.47 |
| CHEMBL445002 | — | — | 1 | 7.55 |
| CHEMBL499947 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239844 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL54331 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL451671 | — | IC50 | = | 3.38 | nM | 8.47 |
| CHEMBL445002 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL499947 | — | IC50 | = | 56.0 | nM | 7.25 |