Assay Detail
Binding
CHEMBL1006239
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Inhibition of ITK in chicken DT40 B cells assessed as calcium flux inhibition assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Cell Type | B |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5-Aminomethyl-1H-benzimidazoles as orally active inhibitors of inducible T-cell kinase (Itk).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.44 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL528989 | — | — | 1 | 7.12 |
| CHEMBL460824 | — | — | 1 | 6.47 |
| CHEMBL486757 | — | — | 1 | 6.39 |
| CHEMBL488398 | — | — | 1 | 6.27 |
| CHEMBL488187 | — | — | 1 | 6.22 |
| CHEMBL487982 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL528989 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL460824 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL486757 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL488398 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL488187 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL487982 | — | IC50 | = | 650.0 | nM | 6.19 |