Assay Detail
Functional
CHEMBL1006487
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Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.67 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9416 | ISOBUTYLSHIKONIN | — | 1 | 6.66 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.62 |
| CHEMBL507545 | — | — | 1 | 6.47 |
| CHEMBL403516 | ACETYLSHIKONIN | — | 1 | 6.42 |
| CHEMBL112415 | ACETYLALKANNIN | — | 1 | 6.41 |
| CHEMBL453856 | ISOBUTYLALKANNIN | — | 1 | 6.38 |
| CHEMBL453082 | ETHYLSHIKONIN | — | 1 | 6.38 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | — | 1 | 6.23 |
| CHEMBL11475 | — | — | 1 | 5.63 |
| CHEMBL289277 | EMODIN | — | 1 | 5.28 |
| CHEMBL40275 | ALOE-EMODIN | — | 1 | 5.00 |
| CHEMBL418068 | RHEIN | — | 1 | 4.91 |
| CHEMBL2368547 | Sennoside A | — | 1 | 4.29 |
| CHEMBL41092 | CHRYSOPHANOL | — | 1 | 4.19 |
| CHEMBL42624 | PHYSCION | — | 1 | 4.11 |
| CHEMBL521045 | — | — | 1 | - |
| CHEMBL507566 | — | — | 1 | - |
| CHEMBL454428 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9416 | ISOBUTYLSHIKONIN | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL507545 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL403516 | ACETYLSHIKONIN | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL112415 | ACETYLALKANNIN | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL453856 | ISOBUTYLALKANNIN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL453082 | ETHYLSHIKONIN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL397309 | BETA-HYDROXYISOVALERYLSHIKONIN | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL11475 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL289277 | EMODIN | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL40275 | ALOE-EMODIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL418068 | RHEIN | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL2368547 | Sennoside A | IC50 | = | 51600.0 | nM | 4.29 |
| CHEMBL41092 | CHRYSOPHANOL | IC50 | = | 64400.0 | nM | 4.19 |
| CHEMBL42624 | PHYSCION | IC50 | = | 77300.0 | nM | 4.11 |
| CHEMBL521045 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL507566 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL454428 | — | IC50 | > | 100000.0 | nM | - |