Assay Detail
Binding
CHEMBL1006645
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Inhibition of human recombinant caspase 7 assessed as accumulation of cleaved fluorogenic 7-amino-4-methylcoumarin after 10 mins
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.43 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL467252 | — | — | 1 | 9.22 |
| CHEMBL523666 | — | — | 1 | 8.72 |
| CHEMBL494220 | — | — | 1 | 8.62 |
| CHEMBL466422 | — | — | 1 | 8.30 |
| CHEMBL513663 | — | — | 1 | 8.14 |
| CHEMBL492385 | — | — | 1 | 8.12 |
| CHEMBL513297 | — | — | 1 | 8.05 |
| CHEMBL467251 | — | — | 1 | 7.80 |
| CHEMBL512101 | — | — | 1 | 7.62 |
| CHEMBL511723 | — | — | 1 | 7.37 |
| CHEMBL468088 | — | — | 1 | 7.30 |
| CHEMBL466423 | — | — | 1 | 7.21 |
| CHEMBL521984 | — | — | 1 | 7.21 |
| CHEMBL493374 | — | — | 1 | 7.17 |
| CHEMBL493375 | — | — | 1 | 7.00 |
| CHEMBL513513 | — | — | 1 | 6.96 |
| CHEMBL62993 | — | — | 1 | 6.53 |
| CHEMBL293034 | — | — | 1 | 6.52 |
| CHEMBL524017 | — | — | 1 | 6.46 |
| CHEMBL60190 | — | — | 1 | 5.89 |
| CHEMBL466007 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL467252 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL523666 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL494220 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL466422 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL513663 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL492385 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL513297 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL467251 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL512101 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL511723 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL468088 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL466423 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL521984 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL493374 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL493375 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL513513 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL62993 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL293034 | — | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL524017 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL60190 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL466007 | — | IC50 | = | 1660.0 | nM | 5.78 |