Assay Detail
Binding
CHEMBL1006827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of bovine brain tubulin assembly
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antineoplastic agents. 515. Synthesis of human cancer cell growth inhibitors derived from 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.82 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | 2.0 | 1 | 6.16 |
| CHEMBL503466 | — | — | 1 | 5.89 |
| CHEMBL506246 | — | — | 1 | 5.85 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.75 |
| CHEMBL147075 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39541 | DOLASTATIN-10 | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL503466 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL506246 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL147075 | — | IC50 | = | 3400.0 | nM | 5.47 |