Assay Detail
Functional
CHEMBL1006918
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Cytotoxicity against human KB cells after 72 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.37 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.70 |
| CHEMBL294323 | — | — | 1 | 5.68 |
| CHEMBL465475 | — | — | 1 | 5.19 |
| CHEMBL512065 | OCHRACEOLIDE A | — | 1 | 4.69 |
| CHEMBL507001 | DIOSCIN | — | 1 | 4.68 |
| CHEMBL441441 | ALPHA-LAPACHONE | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL294323 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL465475 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL512065 | OCHRACEOLIDE A | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL507001 | DIOSCIN | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL441441 | ALPHA-LAPACHONE | IC50 | = | 53700.0 | nM | 4.27 |