Assay Detail
Binding
CHEMBL1006964
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-fused recombinant HAT p300 expressed in Escherichia coli by filter assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis of isothiazol-3-one derivatives as inhibitors of histone acetyltransferases (HATs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.91 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499919 | — | — | 1 | 5.52 |
| CHEMBL491092 | — | — | 1 | 5.00 |
| CHEMBL487498 | — | — | 1 | 4.84 |
| CHEMBL99594 | — | — | 1 | 4.64 |
| CHEMBL489494 | — | — | 1 | 4.55 |
| CHEMBL443951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499919 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL491092 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL487498 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL99594 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL489494 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL443951 | — | IC50 | - | — | - |