Assay Detail
Binding
CHEMBL1007110
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Binding affinity to Trypanosoma cruzi CYP51 expressed in Escherichia coli by spectral titration
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sterol 14-alpha demethylase (CHEMBL1075110) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma cruzi (strain CL Brener) |
Publication
Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 13 | 6.21 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473679 | — | — | 1 | 6.82 |
| CHEMBL474704 | — | — | 1 | 6.62 |
| CHEMBL470642 | — | — | 1 | 6.58 |
| CHEMBL329480 | — | — | 1 | 6.54 |
| CHEMBL469820 | — | — | 1 | 6.44 |
| CHEMBL484729 | — | — | 1 | 6.43 |
| CHEMBL507264 | — | — | 1 | 6.36 |
| CHEMBL521330 | — | — | 1 | 6.27 |
| CHEMBL470641 | — | — | 1 | 6.25 |
| CHEMBL474703 | — | — | 1 | 6.12 |
| CHEMBL469819 | — | — | 1 | 5.64 |
| CHEMBL484730 | — | — | 1 | 5.48 |
| CHEMBL519512 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473679 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL474704 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL470642 | — | Kd | = | 260.0 | nM | 6.58 |
| CHEMBL329480 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL469820 | — | Kd | = | 360.0 | nM | 6.44 |
| CHEMBL484729 | — | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL507264 | — | Kd | = | 440.0 | nM | 6.36 |
| CHEMBL521330 | — | Kd | = | 540.0 | nM | 6.27 |
| CHEMBL470641 | — | Kd | = | 560.0 | nM | 6.25 |
| CHEMBL474703 | — | Kd | = | 750.0 | nM | 6.12 |
| CHEMBL469819 | — | Kd | = | 2310.0 | nM | 5.64 |
| CHEMBL484730 | — | Kd | = | 3300.0 | nM | 5.48 |
| CHEMBL519512 | — | Kd | = | 7600.0 | nM | 5.12 |