Assay Detail
Binding
CHEMBL1007243
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Binding affinity to calf thymus DNA at 3 uM by fluorescence spectrophotometric titration
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Oxoisoaporphine alkaloid derivatives: synthesis, DNA binding affinity and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 4.77 | 5.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL395927 | — | — | 1 | 5.31 |
| CHEMBL461133 | — | — | 1 | 4.98 |
| CHEMBL245472 | — | — | 1 | 4.91 |
| CHEMBL246912 | — | — | 1 | 4.84 |
| CHEMBL248534 | — | — | 1 | 4.78 |
| CHEMBL397782 | — | — | 1 | 4.75 |
| CHEMBL429291 | — | — | 1 | 4.62 |
| CHEMBL462560 | — | — | 1 | 4.59 |
| CHEMBL246911 | — | — | 1 | 4.59 |
| CHEMBL245471 | — | — | 1 | 4.57 |
| CHEMBL245670 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL395927 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL461133 | — | Ki | = | 10400.0 | nM | 4.98 |
| CHEMBL245472 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL246912 | — | Ki | = | 14500.0 | nM | 4.84 |
| CHEMBL248534 | — | Ki | = | 16800.0 | nM | 4.78 |
| CHEMBL397782 | — | Ki | = | 17900.0 | nM | 4.75 |
| CHEMBL429291 | — | Ki | = | 23900.0 | nM | 4.62 |
| CHEMBL462560 | — | Ki | = | 25500.0 | nM | 4.59 |
| CHEMBL246911 | — | Ki | = | 25400.0 | nM | 4.59 |
| CHEMBL245471 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL245670 | — | Ki | = | 31700.0 | nM | 4.50 |