Assay Detail
Functional
CHEMBL1007244
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Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Oxoisoaporphine alkaloid derivatives: synthesis, DNA binding affinity and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.06 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397782 | — | — | 1 | 5.68 |
| CHEMBL245670 | — | — | 1 | 5.63 |
| CHEMBL462560 | — | — | 1 | 5.37 |
| CHEMBL429291 | — | — | 1 | 5.30 |
| CHEMBL245471 | — | — | 1 | 5.17 |
| CHEMBL248534 | — | — | 1 | 5.04 |
| CHEMBL246912 | — | — | 1 | 5.04 |
| CHEMBL246911 | — | — | 1 | 4.78 |
| CHEMBL245472 | — | — | 1 | 4.71 |
| CHEMBL395927 | — | — | 1 | 4.52 |
| CHEMBL246681 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397782 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL245670 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL462560 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL429291 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL245471 | — | IC50 | = | 6710.0 | nM | 5.17 |
| CHEMBL248534 | — | IC50 | = | 9220.0 | nM | 5.04 |
| CHEMBL246912 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL246911 | — | IC50 | = | 16720.0 | nM | 4.78 |
| CHEMBL245472 | — | IC50 | = | 19290.0 | nM | 4.71 |
| CHEMBL395927 | — | IC50 | = | 30260.0 | nM | 4.52 |
| CHEMBL246681 | — | IC50 | = | 35530.0 | nM | 4.45 |