Assay Detail
Functional
CHEMBL1007245
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Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Oxoisoaporphine alkaloid derivatives: synthesis, DNA binding affinity and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.97 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245670 | — | — | 1 | 5.41 |
| CHEMBL462560 | — | — | 1 | 5.20 |
| CHEMBL245471 | — | — | 1 | 5.11 |
| CHEMBL397782 | — | — | 1 | 5.09 |
| CHEMBL246911 | — | — | 1 | 5.09 |
| CHEMBL248534 | — | — | 1 | 5.01 |
| CHEMBL429291 | — | — | 1 | 4.92 |
| CHEMBL246912 | — | — | 1 | 4.89 |
| CHEMBL246681 | — | — | 1 | 4.71 |
| CHEMBL395927 | — | — | 1 | 4.68 |
| CHEMBL245472 | — | — | 1 | 4.53 |
| CHEMBL461133 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245670 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL462560 | — | IC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL245471 | — | IC50 | = | 7740.0 | nM | 5.11 |
| CHEMBL397782 | — | IC50 | = | 8140.0 | nM | 5.09 |
| CHEMBL246911 | — | IC50 | = | 8180.0 | nM | 5.09 |
| CHEMBL248534 | — | IC50 | = | 9690.0 | nM | 5.01 |
| CHEMBL429291 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL246912 | — | IC50 | = | 12940.0 | nM | 4.89 |
| CHEMBL246681 | — | IC50 | = | 19680.0 | nM | 4.71 |
| CHEMBL395927 | — | IC50 | = | 21020.0 | nM | 4.68 |
| CHEMBL245472 | — | IC50 | = | 29830.0 | nM | 4.53 |
| CHEMBL461133 | — | IC50 | > | 100000.0 | nM | - |