Assay Detail
Functional
CHEMBL1007338
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Cytotoxicity against human A549 cells by SRB assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of C-12' substituted vinflunine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 5.82 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506461 | — | — | 1 | 7.43 |
| CHEMBL504298 | — | — | 1 | 7.30 |
| CHEMBL2110725 | VINFLUNINE | 4.0 | 1 | 7.10 |
| CHEMBL449562 | — | — | 1 | 6.92 |
| CHEMBL526188 | — | — | 1 | 6.80 |
| CHEMBL508443 | — | — | 1 | 6.70 |
| CHEMBL503541 | — | — | 1 | 6.66 |
| CHEMBL508944 | — | — | 1 | 6.55 |
| CHEMBL505688 | — | — | 1 | 6.54 |
| CHEMBL445190 | — | — | 1 | 6.54 |
| CHEMBL503820 | — | — | 1 | 6.50 |
| CHEMBL510609 | — | — | 1 | 6.38 |
| CHEMBL511004 | — | — | 1 | 6.29 |
| CHEMBL509111 | — | — | 1 | 6.25 |
| CHEMBL504496 | — | — | 1 | 6.19 |
| CHEMBL501105 | — | — | 1 | 6.04 |
| CHEMBL504570 | — | — | 1 | 6.00 |
| CHEMBL455251 | — | — | 1 | 5.99 |
| CHEMBL508145 | — | — | 1 | 5.99 |
| CHEMBL500742 | — | — | 1 | 5.93 |
| CHEMBL507685 | — | — | 1 | 5.76 |
| CHEMBL507647 | — | — | 1 | 5.74 |
| CHEMBL499383 | — | — | 1 | 5.73 |
| CHEMBL501106 | — | — | 1 | 5.73 |
| CHEMBL510633 | — | — | 1 | 5.67 |
| CHEMBL443421 | — | — | 1 | 5.64 |
| CHEMBL503484 | — | — | 1 | 5.60 |
| CHEMBL500314 | — | — | 1 | 5.59 |
| CHEMBL524723 | — | — | 1 | 5.52 |
| CHEMBL502900 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506461 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL504298 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2110725 | VINFLUNINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL449562 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL526188 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL508443 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL503541 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL508944 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL505688 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL445190 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL503820 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL510609 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL511004 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL509111 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL504496 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL501105 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL504570 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL455251 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL508145 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL500742 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL507685 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL507647 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL499383 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL501106 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL510633 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL443421 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL503484 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL500314 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL524723 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL502900 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL510475 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL501978 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL502757 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL449190 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL500026 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL443249 | — | IC50 | = | 6910.0 | nM | 5.16 |
| CHEMBL505964 | — | IC50 | = | 8730.0 | nM | 5.06 |
| CHEMBL449226 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL504168 | — | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL526493 | — | IC50 | = | 35100.0 | nM | 4.46 |
| CHEMBL503178 | — | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL502425 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL499040 | — | IC50 | = | 95500.0 | nM | 4.02 |
| CHEMBL446507 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL500294 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL499195 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL509723 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL525414 | — | IC50 | > | 100000.0 | nM | - |