Assay Detail
Binding
CHEMBL1007389
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Activation of FKBP12-rapamycin binding domain A2020V I2021T D2096G stop codon mutant in african green monkey COS1 cells after 16 hrs assessed as induction of secreted alkaline phosphatase expression assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | COS-1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The rapamycin-binding domain of the protein kinase mammalian target of rapamycin is a destabilizing domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.38 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503885 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503885 | — | EC50 | = | 41.7 | nM | 7.38 |