Assay Detail
Binding
CHEMBL1007398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Blockade of neutrophil elastase processing in human U937 cells after 7 days by fluorogenic substrate cleavage assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.38 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL515494 | — | — | 1 | 6.77 |
| CHEMBL516292 | — | — | 1 | 6.66 |
| CHEMBL1162477 | — | — | 1 | 5.72 |
| CHEMBL478737 | — | — | 1 | - |
| CHEMBL400387 | — | — | 1 | - |
| CHEMBL63440 | ALOXISTATIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL515494 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL516292 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1162477 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL478737 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL400387 | — | IC50 | - | — | - | |
| CHEMBL63440 | ALOXISTATIN | IC50 | - | — | - |