Assay Detail
Binding
CHEMBL1007512
Review assay metadata, readout intent, target linkage, and publication context from the same page.
inhibition of human recombinant MMP2 catalytic domain
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and activity of quinolinylmethyl P1' alpha-sulfone piperidine hydroxamate inhibitors of TACE.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.99 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212481 | — | — | 1 | 7.21 |
| CHEMBL499854 | — | — | 1 | 7.02 |
| CHEMBL447275 | — | — | 1 | 6.84 |
| CHEMBL380049 | — | — | 1 | 6.47 |
| CHEMBL502796 | — | — | 1 | 6.29 |
| CHEMBL524533 | — | — | 1 | 6.07 |
| CHEMBL503067 | — | — | 1 | 5.96 |
| CHEMBL497838 | — | — | 1 | 5.91 |
| CHEMBL495831 | — | — | 1 | 5.85 |
| CHEMBL385821 | — | — | 1 | 5.80 |
| CHEMBL496619 | — | — | 1 | 5.76 |
| CHEMBL496423 | — | — | 1 | 5.67 |
| CHEMBL499313 | — | — | 1 | 5.57 |
| CHEMBL497012 | — | — | 1 | 5.44 |
| CHEMBL498032 | — | — | 1 | 5.16 |
| CHEMBL495795 | — | — | 1 | 4.82 |
| CHEMBL495621 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212481 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL499854 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL447275 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL380049 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL502796 | — | IC50 | = | 516.0 | nM | 6.29 |
| CHEMBL524533 | — | IC50 | = | 855.0 | nM | 6.07 |
| CHEMBL503067 | — | IC50 | = | 1093.0 | nM | 5.96 |
| CHEMBL497838 | — | IC50 | = | 1241.0 | nM | 5.91 |
| CHEMBL495831 | — | IC50 | = | 1401.0 | nM | 5.85 |
| CHEMBL385821 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL496619 | — | IC50 | = | 1743.0 | nM | 5.76 |
| CHEMBL496423 | — | IC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL499313 | — | IC50 | = | 2674.0 | nM | 5.57 |
| CHEMBL497012 | — | IC50 | = | 3614.0 | nM | 5.44 |
| CHEMBL498032 | — | IC50 | = | 6958.0 | nM | 5.16 |
| CHEMBL495795 | — | IC50 | = | 15099.0 | nM | 4.82 |
| CHEMBL495621 | — | IC50 | > | 15000.0 | nM | - |