Assay Detail
Binding
CHEMBL1007513
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inhibition of human recombinant MMP13 catalytic domain
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and activity of quinolinylmethyl P1' alpha-sulfone piperidine hydroxamate inhibitors of TACE.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.42 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499854 | — | — | 1 | 7.24 |
| CHEMBL212481 | — | — | 1 | 7.23 |
| CHEMBL496618 | — | — | 1 | 7.14 |
| CHEMBL447275 | — | — | 1 | 7.10 |
| CHEMBL526646 | — | — | 1 | 6.98 |
| CHEMBL236572 | — | — | 1 | 6.87 |
| CHEMBL524281 | — | — | 1 | 6.87 |
| CHEMBL380049 | — | — | 1 | 6.81 |
| CHEMBL502796 | — | — | 1 | 6.69 |
| CHEMBL524533 | — | — | 1 | 6.58 |
| CHEMBL497413 | — | — | 1 | 6.55 |
| CHEMBL503067 | — | — | 1 | 6.46 |
| CHEMBL496619 | — | — | 1 | 6.41 |
| CHEMBL497838 | — | — | 1 | 6.38 |
| CHEMBL495831 | — | — | 1 | 6.36 |
| CHEMBL497012 | — | — | 1 | 6.08 |
| CHEMBL496423 | — | — | 1 | 6.03 |
| CHEMBL499313 | — | — | 1 | 5.96 |
| CHEMBL498032 | — | — | 1 | 5.87 |
| CHEMBL495795 | — | — | 1 | 5.84 |
| CHEMBL385821 | — | — | 1 | 5.72 |
| CHEMBL495629 | — | — | 1 | 5.40 |
| CHEMBL495621 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499854 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL212481 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL496618 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL447275 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL526646 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL236572 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL524281 | — | IC50 | = | 136.0 | nM | 6.87 |
| CHEMBL380049 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL502796 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL524533 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL497413 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL503067 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL496619 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL497838 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL495831 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL497012 | — | IC50 | = | 835.0 | nM | 6.08 |
| CHEMBL496423 | — | IC50 | = | 926.0 | nM | 6.03 |
| CHEMBL499313 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL498032 | — | IC50 | = | 1336.0 | nM | 5.87 |
| CHEMBL495795 | — | IC50 | = | 1451.0 | nM | 5.84 |
| CHEMBL385821 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL495629 | — | IC50 | = | 4019.0 | nM | 5.40 |
| CHEMBL495621 | — | IC50 | = | 8624.0 | nM | 5.06 |