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Assay Detail

CHEMBL1007542

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human MCF7 cells after 4 days by MTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.
Song Y, Liu CI, Lin FY, No JH, Hensler M, Liu YL, Jeng WY, Low J, Liu GY, Nizet V, Wang AH, Oldfield E.
J Med Chem (2009) 52 : 3869 -3880
PubMed 19456099 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.16 4.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL496803 1 4.16
CHEMBL495623 1 -
CHEMBL495624 1 -
CHEMBL497634 1 -
CHEMBL497635 1 -
CHEMBL497616 1 -
CHEMBL497617 1 -
CHEMBL497815 1 -
CHEMBL497410 1 -
CHEMBL497618 1 -
CHEMBL524084 1 -
CHEMBL496801 1 -
CHEMBL496802 1 -
CHEMBL449115 1 -
CHEMBL498628 1 -
CHEMBL525377 1 -
CHEMBL523897 1 -
CHEMBL447414 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL496803 IC50 = 69000.0 nM 4.16
CHEMBL495623 IC50 > 300000.0 nM -
CHEMBL495624 IC50 > 300000.0 nM -
CHEMBL497634 IC50 > 300000.0 nM -
CHEMBL497635 IC50 > 300000.0 nM -
CHEMBL497616 IC50 > 300000.0 nM -
CHEMBL497617 IC50 > 300000.0 nM -
CHEMBL497815 IC50 > 300000.0 nM -
CHEMBL497410 IC50 > 300000.0 nM -
CHEMBL497618 IC50 > 300000.0 nM -
CHEMBL524084 IC50 > 300000.0 nM -
CHEMBL496801 IC50 > 300000.0 nM -
CHEMBL496802 IC50 > 300000.0 nM -
CHEMBL449115 IC50 = 135000.0 nM -
CHEMBL498628 IC50 > 300000.0 nM -
CHEMBL525377 IC50 = 266000.0 nM -
CHEMBL523897 IC50 = 283000.0 nM -
CHEMBL447414 IC50 > 300000.0 nM -