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Assay Detail

CHEMBL1007903

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to OX2 receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Orexin receptor type 2 (CHEMBL4792)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
Boss C, Brisbare-Roch C, Jenck F.
J Med Chem (2009) 52 : 891 -903
PubMed 19199652 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 5.60 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL363743 1 5.70
CHEMBL185136 1 5.60
CHEMBL359632 1 5.50
CHEMBL183786 1 -
CHEMBL363951 1 -
CHEMBL184384 1 -
CHEMBL361748 1 -
CHEMBL185435 1 -
CHEMBL185382 1 -
CHEMBL185219 1 -
CHEMBL361716 1 -
CHEMBL182473 1 -
CHEMBL185093 1 -
CHEMBL185088 1 -
CHEMBL184936 1 -
CHEMBL185080 1 -
CHEMBL360377 1 -
CHEMBL183576 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL363743 Ki = 1995.26 nM 5.70
CHEMBL185136 Ki = 2511.89 nM 5.60
CHEMBL359632 Ki = 3162.28 nM 5.50
CHEMBL183786 Ki > 10000.0 nM -
CHEMBL363951 Ki > 10000.0 nM -
CHEMBL184384 Ki > 10000.0 nM -
CHEMBL361748 Ki > 10000.0 nM -
CHEMBL185435 Ki > 10000.0 nM -
CHEMBL185382 Ki > 5011.87 nM -
CHEMBL185219 Ki > 10000.0 nM -
CHEMBL361716 Ki > 5011.87 nM -
CHEMBL182473 Ki > 5011.87 nM -
CHEMBL185093 Ki > 10000.0 nM -
CHEMBL185088 Ki > 5011.87 nM -
CHEMBL184936 Ki > 10000.0 nM -
CHEMBL185080 Ki > 10000.0 nM -
CHEMBL360377 Ki > 10000.0 nM -
CHEMBL183576 Ki > 10000.0 nM -