Assay Detail
Binding
CHEMBL1007908
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Inhibition of OX1 receptor
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 6.43 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493016 | — | — | 1 | 8.10 |
| CHEMBL455136 | ALMOREXANT | 3.0 | 1 | 7.89 |
| CHEMBL489884 | — | — | 1 | 7.75 |
| CHEMBL493427 | — | — | 1 | 7.72 |
| CHEMBL444407 | — | — | 1 | 7.68 |
| CHEMBL490082 | — | — | 1 | 7.43 |
| CHEMBL522786 | — | — | 1 | 7.36 |
| CHEMBL489685 | — | — | 1 | 7.35 |
| CHEMBL490484 | — | — | 1 | 7.31 |
| CHEMBL451281 | — | — | 1 | 7.28 |
| CHEMBL521649 | — | — | 1 | 7.12 |
| CHEMBL489485 | — | — | 1 | 6.93 |
| CHEMBL490489 | — | — | 1 | 6.92 |
| CHEMBL489284 | — | — | 1 | 6.90 |
| CHEMBL523963 | — | — | 1 | 6.89 |
| CHEMBL490885 | — | — | 1 | 6.70 |
| CHEMBL491086 | — | — | 1 | 6.57 |
| CHEMBL454924 | — | — | 1 | 6.26 |
| CHEMBL490291 | — | — | 1 | 6.16 |
| CHEMBL491468 | — | — | 1 | 6.14 |
| CHEMBL522927 | — | — | 1 | 5.95 |
| CHEMBL491278 | — | — | 1 | 5.94 |
| CHEMBL489303 | — | — | 1 | 5.93 |
| CHEMBL524139 | — | — | 1 | 5.84 |
| CHEMBL522975 | — | — | 1 | 5.80 |
| CHEMBL489686 | — | — | 1 | 5.72 |
| CHEMBL490290 | — | — | 1 | 5.70 |
| CHEMBL522957 | — | — | 1 | 5.50 |
| CHEMBL489289 | — | — | 1 | 5.37 |
| CHEMBL524093 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493016 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL455136 | ALMOREXANT | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL489884 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL493427 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL444407 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL490082 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL522786 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL489685 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL490484 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL451281 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL521649 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL489485 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL490489 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL489284 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL523963 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL490885 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL491086 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL454924 | — | IC50 | = | 552.0 | nM | 6.26 |
| CHEMBL490291 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL491468 | — | IC50 | = | 731.0 | nM | 6.14 |
| CHEMBL522927 | — | IC50 | = | 1113.0 | nM | 5.95 |
| CHEMBL491278 | — | IC50 | = | 1138.0 | nM | 5.94 |
| CHEMBL489303 | — | IC50 | = | 1182.0 | nM | 5.93 |
| CHEMBL524139 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL522975 | — | IC50 | = | 1565.0 | nM | 5.80 |
| CHEMBL489686 | — | IC50 | = | 1906.0 | nM | 5.72 |
| CHEMBL490290 | — | IC50 | = | 2008.0 | nM | 5.70 |
| CHEMBL522957 | — | IC50 | = | 3138.0 | nM | 5.50 |
| CHEMBL489289 | — | IC50 | = | 4274.0 | nM | 5.37 |
| CHEMBL524093 | — | IC50 | = | 4464.0 | nM | 5.35 |
| CHEMBL490681 | — | IC50 | = | 4771.0 | nM | 5.32 |
| CHEMBL490877 | — | IC50 | = | 5731.0 | nM | 5.24 |
| CHEMBL489288 | — | IC50 | = | 8425.0 | nM | 5.07 |
| CHEMBL521579 | — | IC50 | = | 9475.0 | nM | 5.02 |
| CHEMBL522443 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL490675 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489478 | — | IC50 | > | 10000.0 | nM | - |