Assay Detail
Binding
CHEMBL1007909
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Inhibition of OX2 receptor
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Biomedical application of orexin/hypocretin receptor ligands in neuroscience.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.85 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455136 | ALMOREXANT | 3.0 | 1 | 8.10 |
| CHEMBL454924 | — | — | 1 | 7.85 |
| CHEMBL489686 | — | — | 1 | 7.72 |
| CHEMBL490082 | — | — | 1 | 7.10 |
| CHEMBL493427 | — | — | 1 | 7.00 |
| CHEMBL493016 | — | — | 1 | 6.96 |
| CHEMBL451281 | — | — | 1 | 6.62 |
| CHEMBL489485 | — | — | 1 | 6.55 |
| CHEMBL490484 | — | — | 1 | 6.17 |
| CHEMBL523963 | — | — | 1 | 5.96 |
| CHEMBL489884 | — | — | 1 | 5.93 |
| CHEMBL489685 | — | — | 1 | 5.81 |
| CHEMBL444407 | — | — | 1 | 5.74 |
| CHEMBL521649 | — | — | 1 | 5.74 |
| CHEMBL489284 | — | — | 1 | 5.57 |
| CHEMBL522786 | — | — | 1 | 5.38 |
| CHEMBL522927 | — | — | 1 | 5.25 |
| CHEMBL490877 | — | — | 1 | 5.21 |
| CHEMBL490489 | — | — | 1 | 5.09 |
| CHEMBL490885 | — | — | 1 | 5.02 |
| CHEMBL490291 | — | — | 1 | 5.00 |
| CHEMBL491086 | — | — | 1 | 5.00 |
| CHEMBL522443 | — | — | 1 | 5.00 |
| CHEMBL491278 | — | — | 1 | 5.00 |
| CHEMBL490290 | — | — | 1 | 5.00 |
| CHEMBL490681 | — | — | 1 | 5.00 |
| CHEMBL522957 | — | — | 1 | 5.00 |
| CHEMBL491468 | — | — | 1 | 5.00 |
| CHEMBL522975 | — | — | 1 | 5.00 |
| CHEMBL524093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455136 | ALMOREXANT | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL454924 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL489686 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL490082 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL493427 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL493016 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL451281 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL489485 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL490484 | — | IC50 | = | 679.0 | nM | 6.17 |
| CHEMBL523963 | — | IC50 | = | 1098.0 | nM | 5.96 |
| CHEMBL489884 | — | IC50 | = | 1161.0 | nM | 5.93 |
| CHEMBL489685 | — | IC50 | = | 1536.0 | nM | 5.81 |
| CHEMBL444407 | — | IC50 | = | 1814.0 | nM | 5.74 |
| CHEMBL521649 | — | IC50 | = | 1811.0 | nM | 5.74 |
| CHEMBL489284 | — | IC50 | = | 2686.0 | nM | 5.57 |
| CHEMBL522786 | — | IC50 | = | 4198.0 | nM | 5.38 |
| CHEMBL522927 | — | IC50 | = | 5660.0 | nM | 5.25 |
| CHEMBL490877 | — | IC50 | = | 6103.0 | nM | 5.21 |
| CHEMBL490489 | — | IC50 | = | 8152.0 | nM | 5.09 |
| CHEMBL490885 | — | IC50 | = | 9499.0 | nM | 5.02 |
| CHEMBL490291 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL522975 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL491468 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL522957 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL490681 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL490290 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL491278 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL522443 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL491086 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL524093 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489303 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL524139 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL490675 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489289 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489288 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL521579 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL489478 | — | IC50 | > | 10000.0 | nM | - |