Assay Detail
Functional
CHEMBL1008020
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania donovani MHOM/ET/67/L82
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In pursuit of natural product leads: synthesis and biological evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and its analogues: discovery of N-(2-benzoxazol-2-ylphenyl)benzamides as novel antileishmanial chemotypes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.07 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463985 | — | — | 1 | 7.10 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 6.58 |
| CHEMBL463392 | — | — | 1 | 6.51 |
| CHEMBL516329 | — | — | 1 | 6.29 |
| CHEMBL518535 | — | — | 1 | 6.28 |
| CHEMBL458800 | — | — | 1 | 6.17 |
| CHEMBL463589 | — | — | 1 | 6.07 |
| CHEMBL519040 | — | — | 1 | 6.03 |
| CHEMBL458799 | — | — | 1 | 6.02 |
| CHEMBL485748 | — | — | 1 | 5.93 |
| CHEMBL458801 | — | — | 1 | 5.76 |
| CHEMBL457699 | — | — | 1 | 5.72 |
| CHEMBL514269 | — | — | 1 | 5.71 |
| CHEMBL516007 | — | — | 1 | 5.51 |
| CHEMBL457971 | — | — | 1 | 5.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463985 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL125 | MILTEFOSINE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL463392 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL516329 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL518535 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL458800 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL463589 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL519040 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL458799 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL485748 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL458801 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL457699 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL514269 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL516007 | — | IC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL457971 | — | IC50 | = | 4360.0 | nM | 5.36 |