Assay Detail
Functional
CHEMBL1008258
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Antimalarial activity after 48 hrs against Plasmodium falciparum GCO3 by [3H]hypoxanthine uptake
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.04 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 8.31 |
| CHEMBL1236460 | THIOSTREPTON | — | 1 | 5.64 |
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | 5.57 |
| CHEMBL529 | AZITHROMYCIN | 4.0 | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL1236460 | THIOSTREPTON | IC50 | = | 2277.0 | nM | 5.64 |
| CHEMBL849 | TRICLOSAN | IC50 | = | 2708.0 | nM | 5.57 |
| CHEMBL529 | AZITHROMYCIN | IC50 | = | 22585.0 | nM | 4.65 |