Assay Detail
Functional
CHEMBL1008259
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Antimalarial activity after 96hrs against Plasmodium falciparum 7G8 by [3H]hypoxanthine uptake
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.16 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.38 |
| CHEMBL529 | AZITHROMYCIN | 4.0 | 1 | 6.64 |
| CHEMBL849 | TRICLOSAN | 4.0 | 1 | 6.37 |
| CHEMBL1236460 | THIOSTREPTON | — | 1 | 6.26 |
| CHEMBL1440 | TETRACYCLINE | 4.0 | 1 | 6.16 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 5.84 |
| CHEMBL532 | ERYTHROMYCIN | 4.0 | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 41.6 | nM | 7.38 |
| CHEMBL529 | AZITHROMYCIN | IC50 | = | 228.1 | nM | 6.64 |
| CHEMBL849 | TRICLOSAN | IC50 | = | 424.4 | nM | 6.37 |
| CHEMBL1236460 | THIOSTREPTON | IC50 | = | 554.8 | nM | 6.26 |
| CHEMBL1440 | TETRACYCLINE | IC50 | = | 696.7 | nM | 6.16 |
| CHEMBL1200699 | DOXYCYCLINE | IC50 | = | 1444.1 | nM | 5.84 |
| CHEMBL532 | ERYTHROMYCIN | IC50 | = | 34700.0 | nM | 4.46 |