Assay Detail
Binding
CHEMBL1008284
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Inhibition of HCV 1b J4 NS5B Cdelta 21polymerase over expressed in Escherichia coli assessed as [alpha33P]UTP incorporation
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.76 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372357 | — | — | 1 | 8.00 |
| CHEMBL176058 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372357 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL176058 | — | IC50 | = | 30.0 | nM | 7.52 |