Assay Detail
Functional
CHEMBL1008349
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Induction of apoptosis in human H1299 cells assessed as caspase activation after 48 hrs by HTS assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4-anilino-N-methylthieno[3,2-d]pyrimidines and 4-anilino-N-methylthieno[2,3-d]pyrimidines as potent apoptosis inducers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 6.88 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492399 | VERUBULIN | 2.0 | 1 | 8.22 |
| CHEMBL526313 | — | — | 1 | 7.82 |
| CHEMBL522221 | — | — | 1 | 7.80 |
| CHEMBL502898 | — | — | 1 | 7.60 |
| CHEMBL498221 | — | — | 1 | 7.50 |
| CHEMBL505903 | — | — | 1 | 7.36 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.30 |
| CHEMBL495998 | — | — | 1 | 7.28 |
| CHEMBL498241 | — | — | 1 | 7.04 |
| CHEMBL496792 | — | — | 1 | 6.62 |
| CHEMBL497629 | — | — | 1 | 6.51 |
| CHEMBL496998 | — | — | 1 | 6.47 |
| CHEMBL498218 | — | — | 1 | 6.25 |
| CHEMBL527023 | — | — | 1 | 6.20 |
| CHEMBL205344 | — | — | 1 | 6.16 |
| CHEMBL521555 | — | — | 1 | 5.55 |
| CHEMBL521554 | — | — | 1 | 5.30 |
| CHEMBL526272 | — | — | 1 | - |
| CHEMBL502065 | — | — | 1 | - |
| CHEMBL453786 | — | — | 1 | - |
| CHEMBL452204 | — | — | 1 | - |
| CHEMBL496425 | — | — | 1 | - |
| CHEMBL496793 | — | — | 1 | - |
| CHEMBL496794 | — | — | 1 | - |
| CHEMBL498217 | — | — | 1 | - |
| CHEMBL452657 | — | — | 1 | - |
| CHEMBL498216 | — | — | 1 | - |
| CHEMBL496186 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492399 | VERUBULIN | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL526313 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL522221 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL502898 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL498221 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL505903 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL107 | COLCHICINE | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL495998 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL498241 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL496792 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL497629 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL496998 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL498218 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL527023 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL205344 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL521555 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL521554 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL526272 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL502065 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL453786 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL452204 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL496425 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL496793 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL496794 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL498217 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL452657 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL498216 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL496186 | — | EC50 | > | 10000.0 | nM | - |