Assay Detail
Binding
CHEMBL1008372
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MMP2
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.69 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495596 | — | — | 1 | 8.10 |
| CHEMBL497222 | — | — | 1 | 7.17 |
| CHEMBL496211 | — | — | 1 | 7.09 |
| CHEMBL496018 | — | — | 1 | 7.04 |
| CHEMBL496628 | — | — | 1 | 7.00 |
| CHEMBL521719 | — | — | 1 | 6.97 |
| CHEMBL387202 | — | — | 1 | 6.82 |
| CHEMBL497032 | — | — | 1 | 6.81 |
| CHEMBL496212 | — | — | 1 | 6.75 |
| CHEMBL221857 | — | — | 1 | 6.70 |
| CHEMBL496825 | — | — | 1 | 6.63 |
| CHEMBL523076 | — | — | 1 | 6.57 |
| CHEMBL497026 | — | — | 1 | 6.49 |
| CHEMBL252246 | — | — | 1 | 6.00 |
| CHEMBL496629 | — | — | 1 | 5.96 |
| CHEMBL445717 | — | — | 1 | 5.89 |
| CHEMBL495797 | — | — | 1 | 5.78 |
| CHEMBL496829 | — | — | 1 | - |
| CHEMBL497645 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495596 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL497222 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL496211 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL496018 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL496628 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL521719 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL387202 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL497032 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL496212 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL221857 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL496825 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL523076 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL497026 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL252246 | — | IC50 | = | 998.0 | nM | 6.00 |
| CHEMBL496629 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL445717 | — | IC50 | = | 1277.0 | nM | 5.89 |
| CHEMBL495797 | — | IC50 | = | 1662.0 | nM | 5.78 |
| CHEMBL496829 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL497645 | — | IC50 | > | 5000.0 | nM | - |