Assay Detail
Binding
CHEMBL1008374
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Inhibition of human MMP3
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.30 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445717 | — | — | 1 | 5.30 |
| CHEMBL252246 | — | — | 1 | - |
| CHEMBL495797 | — | — | 1 | - |
| CHEMBL221857 | — | — | 1 | - |
| CHEMBL387202 | — | — | 1 | - |
| CHEMBL521719 | — | — | 1 | - |
| CHEMBL523076 | — | — | 1 | - |
| CHEMBL497026 | — | — | 1 | - |
| CHEMBL497222 | — | — | 1 | - |
| CHEMBL496628 | — | — | 1 | - |
| CHEMBL496829 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445717 | — | IC50 | = | 4999.0 | nM | 5.30 |
| CHEMBL252246 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL495797 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL221857 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL387202 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL521719 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL523076 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL497026 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL497222 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL496628 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL496829 | — | IC50 | > | 5000.0 | nM | - |