Assay Detail

CHEMBL1009015

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Functional

Cytotoxicity against human SF268 cells after 3 days by SRB assay

ChEMBL ↗

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Target

SF-268 (CHEMBL613977) ↗

Open DB target context

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Primary target SF-268

CHEMBL613977

Anchored from Assay target.

Protein identity SF-268

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SF-268
Confidence	1 — Organism
Curated By	Autocuration

Target

SF-268 (CHEMBL613977) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus.

Arslanian RL, Tang L, Blough S, Ma W, Qiu RG, Katz L, Carney JR.
J Nat Prod (2002) 65 : 1061 -1064
PubMed 12141877 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.63	7.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL96172	EPOTHILONE D	2.0	1	7.85
CHEMBL453818	—	—	1	7.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL96172	EPOTHILONE D	IC50	=	14.0	nM	7.85
CHEMBL453818	—	IC50	=	40.0	nM	7.40