Assay Detail
Functional
CHEMBL1009027
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake
58
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiplasmodial activity of alkaloids from various strychnos species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.72 | 8.30 |
| IC90 | 26 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 2 | 8.30 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 7.50 |
| CHEMBL496076 | ISOSTRYCHNOPENTAMINE | — | 2 | 6.98 |
| CHEMBL170 | QUININE | 4.0 | 2 | 6.70 |
| CHEMBL507761 | — | — | 2 | 6.68 |
| CHEMBL459625 | OCHROLIFUANINE A | — | 2 | 6.58 |
| CHEMBL505314 | MATOPENSINE | — | 4 | 6.44 |
| CHEMBL501860 | STRYCHNOGUCINE B | — | 2 | 6.28 |
| CHEMBL507687 | LONGICAUDATINE | — | 2 | 6.25 |
| CHEMBL486025 | OCHROLIFUANINE E | — | 2 | 6.15 |
| CHEMBL525959 | — | — | 2 | 5.81 |
| CHEMBL450733 | — | — | 2 | 5.67 |
| CHEMBL454188 | — | — | 2 | 5.61 |
| CHEMBL509046 | — | — | 2 | 5.28 |
| CHEMBL486762 | STRYCHNOFURANINE | — | 2 | 4.97 |
| CHEMBL451869 | LONGICAUDATINE F | — | 2 | 4.93 |
| CHEMBL459422 | — | — | 2 | 4.90 |
| CHEMBL518471 | — | — | 2 | 4.89 |
| CHEMBL497541 | PANGANENSINE X | — | 4 | 4.89 |
| CHEMBL529211 | JANUSSINE A | — | 4 | 4.80 |
| CHEMBL453820 | EPINGOUNIENSINE | — | 2 | 4.79 |
| CHEMBL452249 | NGOUNIENSINE | — | 2 | 4.75 |
| CHEMBL459421 | AKAGERINE LACTONE | — | 2 | 4.56 |
| CHEMBL1214432 | USAMBARINE | — | 1 | - |
| CHEMBL490322 | USAMBARENSINE | — | 1 | - |
| CHEMBL520569 | DIHYDROUSAMBARENSINE | — | 1 | - |
| CHEMBL505319 | TETRADEHYDROLONGICAUDATINE Y | — | 1 | - |
| CHEMBL501933 | SUNGUCINE | — | 1 | - |
| CHEMBL524656 | ISOSUNGUCINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL496076 | ISOSTRYCHNOPENTAMINE | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL170 | QUININE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL507761 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL459625 | OCHROLIFUANINE A | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL505314 | MATOPENSINE | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL501860 | STRYCHNOGUCINE B | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL507687 | LONGICAUDATINE | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL486025 | OCHROLIFUANINE E | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL525959 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL450733 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL454188 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL505314 | MATOPENSINE | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL509046 | — | IC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL486762 | STRYCHNOFURANINE | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL451869 | LONGICAUDATINE F | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL459422 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL497541 | PANGANENSINE X | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL518471 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL497541 | PANGANENSINE X | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL529211 | JANUSSINE A | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL453820 | EPINGOUNIENSINE | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL529211 | JANUSSINE A | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL452249 | NGOUNIENSINE | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL459421 | AKAGERINE LACTONE | IC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL501933 | SUNGUCINE | IC50 | - | — | - | |
| CHEMBL507687 | LONGICAUDATINE | IC90 | = | 3640.0 | nM | - |
| CHEMBL505314 | MATOPENSINE | IC90 | = | 4110.0 | nM | - |
| CHEMBL450733 | — | IC90 | = | 7130.0 | nM | - |
| CHEMBL525959 | — | IC90 | = | 9520.0 | nM | - |
| CHEMBL454188 | — | IC90 | = | 11800.0 | nM | - |
| CHEMBL509046 | — | IC90 | = | 12700.0 | nM | - |
| CHEMBL505314 | MATOPENSINE | IC90 | = | 24800.0 | nM | - |
| CHEMBL497541 | PANGANENSINE X | IC90 | = | 26100.0 | nM | - |
| CHEMBL524656 | ISOSUNGUCINE | IC50 | - | — | - | |
| CHEMBL529211 | JANUSSINE A | IC90 | = | 28300.0 | nM | - |
| CHEMBL529211 | JANUSSINE A | IC90 | = | 33100.0 | nM | - |
| CHEMBL459422 | — | IC90 | = | 36300.0 | nM | - |
| CHEMBL505319 | TETRADEHYDROLONGICAUDATINE Y | IC50 | - | — | - | |
| CHEMBL520569 | DIHYDROUSAMBARENSINE | IC50 | - | — | - | |
| CHEMBL490322 | USAMBARENSINE | IC50 | - | — | - | |
| CHEMBL1214432 | USAMBARINE | IC50 | - | — | - | |
| CHEMBL452249 | NGOUNIENSINE | IC90 | = | 62800.0 | nM | - |
| CHEMBL459421 | AKAGERINE LACTONE | IC90 | = | 55200.0 | nM | - |
| CHEMBL451869 | LONGICAUDATINE F | IC90 | = | 33400.0 | nM | - |
| CHEMBL453820 | EPINGOUNIENSINE | IC90 | = | 49700.0 | nM | - |
| CHEMBL486762 | STRYCHNOFURANINE | IC90 | = | 33500.0 | nM | - |
| CHEMBL518471 | — | IC90 | = | 47400.0 | nM | - |
| CHEMBL497541 | PANGANENSINE X | IC90 | = | 43700.0 | nM | - |