Assay Detail
Functional
CHEMBL1009028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake
63
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiplasmodial activity of alkaloids from various strychnos species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.89 | 8.70 |
| IC90 | 31 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 2 | 8.70 |
| CHEMBL520569 | DIHYDROUSAMBARENSINE | — | 2 | 7.50 |
| CHEMBL501860 | STRYCHNOGUCINE B | — | 2 | 7.07 |
| CHEMBL454188 | — | — | 2 | 6.92 |
| CHEMBL525959 | — | — | 2 | 6.91 |
| CHEMBL507761 | — | — | 2 | 6.85 |
| CHEMBL496076 | ISOSTRYCHNOPENTAMINE | — | 2 | 6.82 |
| CHEMBL505314 | MATOPENSINE | — | 4 | 6.61 |
| CHEMBL524656 | ISOSUNGUCINE | — | 2 | 6.58 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 6.55 |
| CHEMBL170 | QUININE | 4.0 | 2 | 6.38 |
| CHEMBL459625 | OCHROLIFUANINE A | — | 2 | 6.31 |
| CHEMBL507687 | LONGICAUDATINE | — | 2 | 6.25 |
| CHEMBL490322 | USAMBARENSINE | — | 2 | 6.23 |
| CHEMBL505319 | TETRADEHYDROLONGICAUDATINE Y | — | 2 | 6.02 |
| CHEMBL486025 | OCHROLIFUANINE E | — | 2 | 5.72 |
| CHEMBL1214432 | USAMBARINE | — | 2 | 5.63 |
| CHEMBL486762 | STRYCHNOFURANINE | — | 2 | 5.55 |
| CHEMBL450733 | — | — | 2 | 5.48 |
| CHEMBL529211 | JANUSSINE A | — | 4 | 5.32 |
| CHEMBL451869 | LONGICAUDATINE F | — | 2 | 5.02 |
| CHEMBL459422 | — | — | 2 | 5.00 |
| CHEMBL501933 | SUNGUCINE | — | 2 | 5.00 |
| CHEMBL453820 | EPINGOUNIENSINE | — | 2 | 4.80 |
| CHEMBL497541 | PANGANENSINE X | — | 4 | 4.77 |
| CHEMBL518471 | — | — | 2 | 4.74 |
| CHEMBL452249 | NGOUNIENSINE | — | 2 | 4.70 |
| CHEMBL459421 | AKAGERINE LACTONE | — | 2 | 4.59 |
| CHEMBL509046 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL520569 | DIHYDROUSAMBARENSINE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL501860 | STRYCHNOGUCINE B | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL454188 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL525959 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL507761 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL496076 | ISOSTRYCHNOPENTAMINE | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL505314 | MATOPENSINE | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL524656 | ISOSUNGUCINE | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL170 | QUININE | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL459625 | OCHROLIFUANINE A | IC50 | = | 492.0 | nM | 6.31 |
| CHEMBL507687 | LONGICAUDATINE | IC50 | = | 569.0 | nM | 6.25 |
| CHEMBL490322 | USAMBARENSINE | IC50 | = | 594.0 | nM | 6.23 |
| CHEMBL505319 | TETRADEHYDROLONGICAUDATINE Y | IC50 | = | 958.0 | nM | 6.02 |
| CHEMBL486025 | OCHROLIFUANINE E | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL1214432 | USAMBARINE | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL486762 | STRYCHNOFURANINE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL450733 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL529211 | JANUSSINE A | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL505314 | MATOPENSINE | IC50 | = | 8660.0 | nM | 5.06 |
| CHEMBL451869 | LONGICAUDATINE F | IC50 | = | 9580.0 | nM | 5.02 |
| CHEMBL501933 | SUNGUCINE | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL459422 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL529211 | JANUSSINE A | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL453820 | EPINGOUNIENSINE | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL497541 | PANGANENSINE X | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL497541 | PANGANENSINE X | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL518471 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL452249 | NGOUNIENSINE | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL459421 | AKAGERINE LACTONE | IC50 | = | 25900.0 | nM | 4.59 |
| CHEMBL507761 | — | IC90 | = | 1350.0 | nM | - |
| CHEMBL496076 | ISOSTRYCHNOPENTAMINE | IC90 | = | 628.0 | nM | - |
| CHEMBL501860 | STRYCHNOGUCINE B | IC90 | = | 358.0 | nM | - |
| CHEMBL269671 | ARTEMISININ | IC90 | = | 17.0 | nM | - |
| CHEMBL454188 | — | IC90 | = | 2260.0 | nM | - |
| CHEMBL459422 | — | IC90 | = | 34600.0 | nM | - |
| CHEMBL451869 | LONGICAUDATINE F | IC90 | = | 28100.0 | nM | - |
| CHEMBL453820 | EPINGOUNIENSINE | IC90 | = | 52800.0 | nM | - |
| CHEMBL529211 | JANUSSINE A | IC90 | = | 27800.0 | nM | - |
| CHEMBL529211 | JANUSSINE A | IC90 | = | 27600.0 | nM | - |
| CHEMBL450733 | — | IC90 | = | 18500.0 | nM | - |
| CHEMBL501933 | SUNGUCINE | IC90 | = | 33200.0 | nM | - |
| CHEMBL452249 | NGOUNIENSINE | IC90 | = | 70100.0 | nM | - |
| CHEMBL497541 | PANGANENSINE X | IC90 | = | 78700.0 | nM | - |
| CHEMBL497541 | PANGANENSINE X | IC90 | = | 85800.0 | nM | - |
| CHEMBL505314 | MATOPENSINE | IC90 | = | 86700.0 | nM | - |
| CHEMBL518471 | — | IC90 | = | 89500.0 | nM | - |
| CHEMBL509046 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL459421 | AKAGERINE LACTONE | IC90 | = | 53300.0 | nM | - |