Assay Detail
Binding
CHEMBL1009210
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Inhibition of ROCK2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Benzimidazole- and benzoxazole-based inhibitors of Rho kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.82 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL454638 | — | — | 1 | 8.70 |
| CHEMBL461338 | — | — | 1 | 8.70 |
| CHEMBL452734 | — | — | 1 | 8.70 |
| CHEMBL462194 | — | — | 1 | 8.22 |
| CHEMBL518825 | — | — | 1 | 8.22 |
| CHEMBL454654 | — | — | 1 | 8.10 |
| CHEMBL453635 | — | — | 1 | 8.05 |
| CHEMBL508975 | — | — | 1 | 8.05 |
| CHEMBL517561 | — | — | 1 | 7.82 |
| CHEMBL509011 | — | — | 1 | 7.68 |
| CHEMBL518665 | — | — | 1 | 7.62 |
| CHEMBL455659 | — | — | 1 | 7.57 |
| CHEMBL454624 | — | — | 1 | 7.57 |
| CHEMBL462193 | — | — | 1 | 7.11 |
| CHEMBL461339 | — | — | 1 | 6.53 |
| CHEMBL517891 | — | — | 1 | 6.53 |
| CHEMBL455658 | — | — | 1 | - |
| CHEMBL454639 | — | — | 1 | - |
| CHEMBL455446 | — | — | 1 | - |
| CHEMBL452598 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL454638 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL461338 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL452734 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL462194 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL518825 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL454654 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL453635 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL508975 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL517561 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL509011 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL518665 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL455659 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL454624 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL462193 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL461339 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL517891 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL455658 | — | IC50 | < | 2.0 | nM | - |
| CHEMBL454639 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL455446 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL452598 | — | IC50 | < | 1.0 | nM | - |