Assay Detail
Binding
CHEMBL1009212
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Benzimidazole- and benzoxazole-based inhibitors of Rho kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.03 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455446 | — | — | 1 | 7.64 |
| CHEMBL455658 | — | — | 1 | 7.60 |
| CHEMBL517561 | — | — | 1 | 7.55 |
| CHEMBL461338 | — | — | 1 | 7.34 |
| CHEMBL454654 | — | — | 1 | 7.18 |
| CHEMBL455659 | — | — | 1 | 7.07 |
| CHEMBL454638 | — | — | 1 | 7.00 |
| CHEMBL454639 | — | — | 1 | 6.67 |
| CHEMBL462194 | — | — | 1 | 6.57 |
| CHEMBL509011 | — | — | 1 | 6.48 |
| CHEMBL508975 | — | — | 1 | 6.27 |
| CHEMBL452598 | — | — | 1 | - |
| CHEMBL518665 | — | — | 1 | - |
| CHEMBL462193 | — | — | 1 | - |
| CHEMBL518825 | — | — | 1 | - |
| CHEMBL517891 | — | — | 1 | - |
| CHEMBL461339 | — | — | 1 | - |
| CHEMBL454624 | — | — | 1 | - |
| CHEMBL452734 | — | — | 1 | - |
| CHEMBL453635 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455446 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL455658 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL517561 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL461338 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL454654 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL455659 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL454638 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL454639 | — | IC50 | = | 212.0 | nM | 6.67 |
| CHEMBL462194 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL509011 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL508975 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL452598 | — | IC50 | < | 6.0 | nM | - |
| CHEMBL518665 | — | IC50 | - | — | - | |
| CHEMBL462193 | — | IC50 | - | — | - | |
| CHEMBL518825 | — | IC50 | - | — | - | |
| CHEMBL517891 | — | IC50 | - | — | - | |
| CHEMBL461339 | — | IC50 | - | — | - | |
| CHEMBL454624 | — | IC50 | - | — | - | |
| CHEMBL452734 | — | IC50 | < | 6.0 | nM | - |
| CHEMBL453635 | — | IC50 | - | — | - |