Assay Detail
Functional
CHEMBL1009241
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Inhibition of compound-48/80 induced degranulation in Wistar rat peritoneal mast cells assessed as histamine release by spectrophotometry
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | mast cells |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| IC50 | 1 | 5.62 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456461 | — | — | 1 | 5.62 |
| CHEMBL468603 | — | — | 1 | - |
| CHEMBL468962 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456461 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL468603 | — | Activity | - | — | - | |
| CHEMBL468962 | — | Activity | - | — | - |