Assay Detail
Functional
CHEMBL1009322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HFF cells after 3 days by methylene blue staining
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and stereochemical effects of pyrrolidinyl-acetylenic thieno[3,2-d]pyrimidines as EGFR and ErbB-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.35 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517123 | GSK-182497A | — | 1 | 5.55 |
| CHEMBL517585 | — | — | 1 | 5.52 |
| CHEMBL451513 | — | — | 1 | 5.46 |
| CHEMBL512076 | GSK-192082A | — | 1 | 5.38 |
| CHEMBL505626 | — | — | 1 | 5.37 |
| CHEMBL507329 | GW869810X | — | 1 | 5.31 |
| CHEMBL466586 | — | — | 1 | 5.30 |
| CHEMBL499534 | — | — | 1 | 5.29 |
| CHEMBL461426 | — | — | 1 | 5.26 |
| CHEMBL504034 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517123 | GSK-182497A | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL517585 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL451513 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL512076 | GSK-192082A | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL505626 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL507329 | GW869810X | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL466586 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL499534 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL461426 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL504034 | — | EC50 | = | 8200.0 | nM | 5.09 |