Assay Detail
Binding
CHEMBL1009880
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Inhibition of Aurora A
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.98 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 8.85 |
| CHEMBL458421 | — | — | 1 | 8.82 |
| CHEMBL516003 | — | — | 1 | 8.55 |
| CHEMBL496569 | — | — | 1 | 8.46 |
| CHEMBL496754 | — | — | 1 | 8.24 |
| CHEMBL522891 | — | — | 1 | 8.23 |
| CHEMBL522563 | — | — | 1 | 8.00 |
| CHEMBL458420 | — | — | 1 | 7.92 |
| CHEMBL523923 | — | — | 1 | 7.89 |
| CHEMBL522214 | — | — | 1 | 7.58 |
| CHEMBL504155 | — | — | 1 | 7.16 |
| CHEMBL495758 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL458421 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL516003 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL496569 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL496754 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL522891 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL522563 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL458420 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL523923 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL522214 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL504155 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL495758 | — | IC50 | = | 910.0 | nM | 6.04 |