Assay Detail
Binding
CHEMBL1009882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK1/Cyclin B
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B1 (CHEMBL1907602) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.90 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522891 | — | — | 1 | 6.64 |
| CHEMBL458421 | — | — | 1 | 6.54 |
| CHEMBL523923 | — | — | 1 | 6.54 |
| CHEMBL496569 | — | — | 1 | 6.47 |
| CHEMBL516003 | — | — | 1 | 5.96 |
| CHEMBL522563 | — | — | 1 | 5.82 |
| CHEMBL496754 | — | — | 1 | 5.54 |
| CHEMBL504155 | — | — | 1 | 5.50 |
| CHEMBL458420 | — | — | 1 | 5.26 |
| CHEMBL522214 | — | — | 1 | 4.77 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522891 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL458421 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL523923 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL496569 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL516003 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL522563 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL496754 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL504155 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL458420 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL522214 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL572878 | TOZASERTIB | IC50 | - | — | - |