Assay Detail
Binding
CHEMBL1009883
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Inhibition of CDK2/Cyclin A
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.29 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522891 | — | — | 1 | 7.28 |
| CHEMBL496569 | — | — | 1 | 6.85 |
| CHEMBL458421 | — | — | 1 | 6.80 |
| CHEMBL523923 | — | — | 1 | 6.80 |
| CHEMBL516003 | — | — | 1 | 6.64 |
| CHEMBL522563 | — | — | 1 | 6.28 |
| CHEMBL504155 | — | — | 1 | 6.00 |
| CHEMBL496754 | — | — | 1 | 5.92 |
| CHEMBL458420 | — | — | 1 | 5.75 |
| CHEMBL495758 | — | — | 1 | 4.55 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | - |
| CHEMBL522214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522891 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL496569 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL458421 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL523923 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL516003 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL522563 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL504155 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL496754 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL458420 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL495758 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL572878 | TOZASERTIB | IC50 | - | — | - | |
| CHEMBL522214 | — | IC50 | - | — | - |