Assay Detail
Binding
CHEMBL1010049
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Inhibition of human recombinant MMP2 transfected in mouse melanoma cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.63 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471537 | — | — | 1 | 9.46 |
| CHEMBL515980 | — | — | 1 | 9.30 |
| CHEMBL472899 | — | — | 1 | 8.92 |
| CHEMBL234530 | — | — | 1 | 8.80 |
| CHEMBL234735 | — | — | 1 | 7.79 |
| CHEMBL456774 | — | — | 1 | 7.61 |
| CHEMBL514138 | CGS-27023A | — | 1 | 7.61 |
| CHEMBL234529 | — | — | 1 | 7.60 |
| CHEMBL450721 | — | — | 1 | 6.84 |
| CHEMBL515083 | — | — | 1 | 6.71 |
| CHEMBL388453 | — | — | 1 | 5.65 |
| CHEMBL388671 | — | — | 1 | 5.29 |
| CHEMBL234737 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471537 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL515980 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL472899 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL234530 | — | IC50 | = | 1.57 | nM | 8.80 |
| CHEMBL234735 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL456774 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 24.8 | nM | 7.61 |
| CHEMBL234529 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL450721 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL515083 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL388453 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL388671 | — | IC50 | = | 5120.0 | nM | 5.29 |
| CHEMBL234737 | — | IC50 | > | 100000.0 | nM | - |