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Assay Detail

CHEMBL1010050

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MMP8
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Neutrophil collagenase (CHEMBL4588)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.
Marques SM, Nuti E, Rossello A, Supuran CT, Tuccinardi T, Martinelli A, Santos MA.
J Med Chem (2008) 51 : 7968 -7979
PubMed 19053764 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 7.64 9.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL471537 1 9.54
CHEMBL515980 1 9.40
CHEMBL234530 1 9.13
CHEMBL472899 1 8.43
CHEMBL456774 1 8.37
CHEMBL514138 CGS-27023A 1 8.11
CHEMBL450721 1 7.54
CHEMBL234735 1 7.46
CHEMBL234529 1 7.23
CHEMBL515083 1 6.00
CHEMBL388453 1 5.36
CHEMBL388671 1 5.09

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL471537 IC50 = 0.29 nM 9.54
CHEMBL515980 IC50 = 0.4 nM 9.40
CHEMBL234530 IC50 = 0.74 nM 9.13
CHEMBL472899 IC50 = 3.7 nM 8.43
CHEMBL456774 IC50 = 4.3 nM 8.37
CHEMBL514138 CGS-27023A IC50 = 7.7 nM 8.11
CHEMBL450721 IC50 = 29.2 nM 7.54
CHEMBL234735 IC50 = 35.0 nM 7.46
CHEMBL234529 IC50 = 59.0 nM 7.23
CHEMBL515083 IC50 = 1010.0 nM 6.00
CHEMBL388453 IC50 = 4360.0 nM 5.36
CHEMBL388671 IC50 = 8200.0 nM 5.09