Assay Detail
Binding
CHEMBL1010054
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Inhibition of MMP16
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.94 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471537 | — | — | 1 | 9.51 |
| CHEMBL234530 | — | — | 1 | 9.00 |
| CHEMBL515980 | — | — | 1 | 8.81 |
| CHEMBL514138 | CGS-27023A | — | 1 | 8.17 |
| CHEMBL472899 | — | — | 1 | 7.94 |
| CHEMBL234529 | — | — | 1 | 7.36 |
| CHEMBL234735 | — | — | 1 | 6.73 |
| CHEMBL515083 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471537 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL234530 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL515980 | — | IC50 | = | 1.56 | nM | 8.81 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL472899 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL234529 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL234735 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL515083 | — | IC50 | = | 996.0 | nM | 6.00 |