Assay Detail
Binding
CHEMBL1010057
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Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.76 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471537 | — | — | 1 | 8.38 |
| CHEMBL51668 | — | — | 1 | 8.30 |
| CHEMBL388671 | — | — | 1 | 8.08 |
| CHEMBL388453 | — | — | 1 | 8.03 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL234735 | — | — | 1 | 7.46 |
| CHEMBL234529 | — | — | 1 | 7.24 |
| CHEMBL234737 | — | — | 1 | 7.20 |
| CHEMBL234530 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471537 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL51668 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL388671 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL388453 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL234735 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL234529 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL234737 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL234530 | — | Ki | = | 65.0 | nM | 7.19 |