Assay Detail
Binding
CHEMBL1010058
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Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydrase assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.97 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL471537 | — | — | 1 | 8.48 |
| CHEMBL388671 | — | — | 1 | 8.42 |
| CHEMBL388453 | — | — | 1 | 8.19 |
| CHEMBL234530 | — | — | 1 | 7.92 |
| CHEMBL234529 | — | — | 1 | 7.89 |
| CHEMBL234735 | — | — | 1 | 7.89 |
| CHEMBL51668 | — | — | 1 | 7.75 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL234737 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL471537 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL388671 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL388453 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL234530 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL234529 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL234735 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL51668 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL234737 | — | Ki | = | 26.0 | nM | 7.58 |